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Check Availability Lawrence Library / Main Collection: QH671 .Y252 2013Library Info

Author LinkYang, Ning.
Title LinkApoptosis / Ning Yang and Ing Swie Goping.
Distribution [San Rafael, Calif.] : Morgan & Claypool, [2013]
©2013.
Description viii, 98 pages :  illustrations (chiefly color) ;  24 cm.
Type of Material Book
Series ( Colloquium series on building blocks of the cell, ;ISSN:2328-3041 ; ; lecture #3 )
Series ( Colloquium series on building blocks of the cell ; # 3.)
Gen. Note E-book is part of: Colloquium digital library of life sciences.
Bibliography Note Includes bibliographical references (pages 77-98).
Contents Contents: Historical perspective of apoptosis -- C. elegans and discovery of the caspases -- Engulfment of apoptotic cells : "find me" and "eat me" signals -- Extrinsic and intrinsic apoptotic signals -- The Bcl-2 family -- Apoptosis and cancer.
Summary "Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson’s, Alzheimer’s). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies."--Page [4] of cover.
Subject LinkApoptosis.
Add.Author LinkGoping, Ing Swie.

System Number 000681111
ISBN Link9781615045389 (pbk.)
Link1615045384 (pbk.)
Link9781615045396 (ebook)
Link1615045392 (ebook)

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